[gecko]

That can't be correct, since I remember running Windows NT 4 on a PowerPC system.

[tesseract]

PowerPC (except PPC970 aka G5, as I recall) is bi-endian (configurable endianness); so are Alpha and Itanium which also had Windows NT ports.

[froydnj]

Alpha is most definitely not a bi-endian architecture; it's little-endian only. PowerPC chips can be either, but the vast, vast majority are big endian.

[kinetik]

Incorrect. The Cray T3E used Alpha processors in big-endian mode.