[xvilka]

The biggest problem that most of the publishers still do not accept LaTeX submissions. Especially if you want to publish a book.

[romwell]

Hello from the world of math! Very sorry to hear about your sufferings.

[Mediterraneo10]

That depends on the field and the specific publisher. Since the turn of the millennium some scholarly presses have stopped accepting LaTeX; this is often related to outsourcing typesetting to Indian shops that are not LaTeX-savvy.