[3PS]

I second this. I've tried Blokada and DNS66 via F-Droid, and Blokada in particular has worked wonders. It blocks ad hosts at the DNS level, which is more battery-efficient than a traditional adblocker, but that also makes it necessary to clear out your DNS cache. I've only had one notable issue that required me to disable Blokada - adding a bank account to Venmo wouldn't work for some reason.

[BrendanEich]

Domain blocking is still crucial, absolutely necessary -- but in our experience no longer sufficient. The adversary has wormed its way into 3rd party domains that sometimes must be allowed in certain 1st parties; it has even wormed its way into 1st parties via actual inside-1p-firewall code, or CNAME hacks to hide in subdomains.

Nothing against Blokada, but as a realist using ad blockers (not just Brave), I need more than domain blocking these days.