[amelius]

Things like this always make me think of: https://en.wikipedia.org/wiki/Fermi_paradox

[pure-awesome]

I assume you are specifically referring to the Great Filter, yes? https://en.wikipedia.org/wiki/Great_Filter

[jobigoud]

Here is John Sotos paper "Biotechnology and the lifetime of technical civilizations" where he looks at the ramifications of a society where any resourceful person will have access to biotechnology capable of killing millions and setting back civilization.

https://arxiv.org/abs/1709.01149