[godson_drafty]

What about releasing a genetically altered strain of the malaria organism itself?

[maxerickson]

Crashing the mosquito population greatly diminishes transmission of the disease.

Because malaria mostly infects humans, if you managed to create a malaria that conferred immunity, you'd have to infect lots and lots of people with it to spread it into the wild, and then it would only infect a subset of the people with the normal malaria strain.

[hsnewman]

Maleria reproduces asexually, so I guess it wouldn't work.

[danieltillett]

Malaria reproduces both sexually and asexually depending on its lifecycle stage.

[gascan]

Immune mosquitoes would be good too, though certainly more challenging to engineer than "kill everything".