Surprisingly difficult for a personal-professional email if you have a somewhat common name. Nearly everything under the main TLDs was bought up ages ago. The issue can be mitigated with some creative branding work, but that’s arguably not any easier.
I've used .io and other "unusual" TLDs for a while and never had an email bounce or flagged as spam.
As someone else pointed out, make sure you setup spf, dkim, and all the other jazz. Some providers will host and setup the dns for you but its always best to use your own dns provider as the records are relatively easy to setup.