[bhk]

> Do you happen to know if rs1229984 is linked to any particular group that could make this result problematic?

It seems to me that we would not have to know about the link in order for the conclusions to be unfounded. These MR analyses rest on the assumption that the instrument is not linked to any potential confounders. This seems like a bold and unwarranted assumption when we are talking about an instrument linked to behavior, given the complexity of the chain of events (chemical, biological, and psychological) between gene expression and observable human behavior.

That education red flag involves just one possible confounder out of many that were never considered.