[subcosmos]

Article is light on a number of things, but I can illuminate some things...

Having worked in one of the largest centers that do this kind of work, the standard practice is to do regression models that predict the atrophy of different brain regions as a function of age. Several longevity studies have implicated grey matter densities in the anterior cingulate cortex as predictive of living for a long time.

Almost all of this prior work has been done with T1 imaging and DTI. SPECT is a new kid on the block, and has a lot of fans and detractors. It's use is somewhat controversial it seems. Someday I'll have time to dig deeper into the tech.

This correlates with low neuroticism scores, and is also a brain region that SSRIs improve grey matter volumes of over the long term.

So remain chill, and prosper