[alangpierce]

There's even plenty of precedent for the same word having different spellings based on region, like with color/colour. I imagine it would be similarly normal to learn that "tomahto" is the British spelling of "tomato" (or whatever it would end up being).

[dsego]

We have that in south slavic languages. For example this word meaning time (or weather) spoken and written differently based on dialect/language: vreme, vrime, vrijeme. [1] Maybe a regional spelling reform could lead to English starting to break apart into several different languages?

[1]https://en.wikipedia.org/wiki/Dialects_of_Serbo-Croatian