There are ways to take most pressure of your spine, while still allowing you to sanely use a mouse/keyboard (the later has to be split). It's mostly a fitted seat with a semi-fancy headrest, the latter has to be designed to keep your head from rolling to the side. Also you need slightly channeled armrests, which need to be adapted in extend/channel depth depending on how far your hands have to move. If you use a steno keyboard, likely not at all, if you use a graphics tablet, likely much further.
You still might need to move every once in a while though.
About this, less hip angle, and with the arms about the same height as the torso (and as such necessitating a split keyboard). For a suitable arm angle you need the head to be higher, which requires some closely fitting head support, which has to even out the pressure on your head. Think a recliner with armrests so your arms can most comfortably type/mouse, and a foam around you neck so you head doesn't roll off to the side. The screen is angled at about 45 degrees downwards, to match the head so you only need to move the eyes.