[Yhippa]

This is just my opinion but I find sans-serif harder to read for long pieces as opposed to serif. Lots of mix of fonts on this page. I have to run most of sites through outline.com to normalize readability.

Of all the MF websites my favorite is this one: http://bettermotherfuckingwebsite.com. It's got good readability like Ali alluded to while loading very fast. Very few colors so that you can focus on what matters most. I feel that unless changing fonts, colors, and sizes adds something legitimate to a user's understanding of the content, skip it.