I've done it once, converting about 15 lines of python to rust. It was completely painless and resulted in a large speedup (changed a hotspot that was taking approximately 90% of execution time in a scientific simulation to approximately 0%).
Type system and expressive macros seems like a big win over c to me.
Care to share a bit more detail on how you did this? Was there some interfacing library that you used analogous to Cython/SWIG/etc.? Presumably you didn't code directly against the C API (in python.h)?
The rust library interfacing with python is https://github.com/dgrunwald/rust-cpython This library understand things like python arrays, objects, etc. and provides nice rust interfaces to them. Basically I just have to write a macro that specifies what functions I'm exposing to python, and other then that I'm writing normal rust. On the python side I'm importing them and calling them like any other python library.
I've mainly been looking at these resources:
https://github.com/rochacbruno/rust-python-example
https://github.com/PyO3/pyo3
Though I have not done rust <-> python in real practice