[furcan]

Appcelerator seems to be the right choice, however developing a 'complex' application (ex: Twitter client) won't be an easy ride.

[goodlab]

SO you'd go native in that case?

[furcan]

I really believe Appcelerator has the right approach in providing a solution for easy, quick, cross platform with native look and feel apps but they aren't there yet. I use Appcelerator for prototyping and if necessary I'll go for native app.