[twoodfin]

I wonder if /u/mikeash can still comment on this thread!

My recent experience has been that indeed inlining is essential for true "zero-cost abstraction"—say an array of integers with index set/get methods—but that once your abstraction is weighty enough that a method is performing more than a few dozen "interesting" instructions, inlining doesn't win much over how well the modern CPU can already optimize across calls.

EDIT: I should add I'm talking about static inlining. I'm sure your typical alien-technology JIT can identify the exact 800 instruction trace in your inner loop and pull it all together into a perfectly machine-sympathetic sequence that runs 50% faster than anything you could construct statically in the absence of profile-driven feedback.