This is an excellent book that discusses human factors at a lot of levels from city planning, to the design of a simple device. It is kind of like a mash up between "Powers of Ten" and a Malcom Gladwell book. Not web centric, but a really good read and intro to HFE.
He is probably talking about the handbook of human factors and ergonomics. It has been updated since I purchased it, and is more information systems focused now. It is like the bible of usability but it is an expensive text, that is why I did not recommend it.
I guess I should have and put a disclaimer on it. When I bought it, it was around $275. If you have to buy one book and you can spare the change, this is the one. But some of the others will get you going faster.
It depends on what you want to do, This book is deeply focused and considered an academic text, many teach from it. Once the subject matter in this book is mastered you will be a HF professional for sure, but some of the other books can get you up and running faster.
At some point you should consider this book for your bookshelf but it is not a beginners book that is another reason I was hesitant to recommend it.
Institutionalization of Usability
User Interfaces for All -- expensive but good.
About Face 2.0 -- Good info poorly written I think 3 may be out by now.
Human Factors in Information Systems