I've been in a few apartments that had novelty floor plans without right angles. All of them were terrible. Granted I have not been in one owned by somebody rich or skilled enough to only have custom made furniture.
I’d be curious to see the effect on airflow, though. I’d gladly pay for custom furniture if the design of the house meant never sitting in a cloud of my own CO2 (without any need for fored-air ventilation like in airplanes/submarines/bunkers.)
I used to go to the IBM Somers campus semi-regularly (IM Pei pyramid-shaped buildings essentially.) It was filled with these weirdly shaped conference and other rooms that made pretty bad use of space.