[say_hello]

Also, I do have concerns about the quality control and dosage accuracy of these supplements. There was a study that tested OTC melatonin products in Canada and found:

> Results show that melatonin content did not meet within a 10-percent margin of the label claim in more than 71 percent of supplements, with the actual content ranging from 83 percent less to 478 percent more than the concentration declared on the label. The study also found that lot-to-lot variability within a particular product varied by as much as 465 percent.

https://www.sciencedaily.com/releases/2017/02/170214162728.h...

There is no reason to believe the situation is different in the US where supplements are not regulated like drugs (thanks, Orrin Hatch).

[joveian]

Good point, that would certainly confuse the situation if there was a 5x variation. Even though they aren't treated the same as drugs there are still quailty standards in the US, although they don't seem to be enforced very well. I try to find suppliers that do better testing. If you have the money for FDA approved stuff you can get ramelteon or tasimelteon these days. But they are quite expensive. Although it looks like the ramelteon patent expires next year and there are a couple of approved generics already so prices should go down quickly next year:

https://www.drugs.com/availability/generic-rozerem.html

I got 1g pure melatonin powder from a now gone supplier that did good quailty testing. It takes me several tries to get something that looks like about .3mg since it is such a tiny amount and I'm sure there is quite a bit of variation, but I'm fairly sure I at least get < .5mg each time.