[vzcx]

Is there some route to naloxone that I am not aware of that doesn't start from some opiate or opium alkaloid? The morphine total syntheses I've read were rather involved and low-yield. Perhaps progress made on the biosynthetic step through reticuline? That would be exciting.

[refurb]

Article covers that. They start with oxycodone. From that a reduction to hydromorphone and then methylation to nalaxone. Not easy chemistry, but only two steps.