[bumholio]

CICO perfectly explains human obesity and has not been scientifically disproved yet - the body is surprisingly efficient at breaking down various types of macronutrients and storing them as fat, regardless of them being "bad" or "good" calories.

What CICO does not explain is why people are so different regarding their appetites, nor how can we teach ourselves impulse control. This is where various low-X diets become relevant, and it's how we get these diet holly wars with people swearing by the one diet that helped them get CI under control, without turning them into zombies incapable of CO.

(BTW, my weapon of choice is old school: low on fat except essential fats, balanced on slow release carbs, high on protein)