Sure, I just don't think that is as much of a paradigm shift as gradual improvement over time. It is not self-driving so much as the deployment of self-driving that will make that change if that makes sense. If everyone drove XC90s on barrier separated roads with automatic traffic cameras that enforced things like speed and distance between cars, we would also be much safer. But it would still be largely the same thing as today.
400,000 lives per year wasted mind numbingly staring at a road and keeping a car driving along it.