[zfrenchee]

Cas9 does not edit DNA, it cleaves DNA. What happens afterwards is up to the cell. The hype machine has ignored this fact.

One of my favorite George Church quotes: "CRISPR: some call it genome editing. I call it genome vandalism".

Base Editors can actually edit DNA, but only single bases at a time. http://www.sciencemag.org/news/2017/10/novel-crispr-derived-...

There's a big prize waiting for the person who can harness DNA repair pathways in conjunction with Cas9 to make precise, multi-base DNA edits. Lots of folks are working on that now.

[21]

Does it cleave a whole segment off (two point cut), or just a single cut?

[distant_hat]

Single cut.