Thanks. I think we meant the same, and it's rather a question where your argumentation's starting point is set, because Wikipedia concurs, that DNA damage is caused by decreasing repair or apoptosis.
Anyway, I think this is where some lifestyle fads can become interesting. Sure, there are definitely some aspects to aging that are unaffected by this, but I think better chances of reaching current max human age are in our hands somewhat. Balancing IGF1 and frequently giving the body a break to repair, kill, and remove trash, are sound targets IMHO. So for me that is: restriction of certein makros, in particular animal proteins and refined carbs, early and midlife to lower IGF1 (raising it seems beneficial in old people); short term fasting every now and then. Both have shown to increase apoptosis and repair. It's not even hard to do, if you stick to a blue zone typical diet (plantbased diets are associated with double digit reduction in overall cancer risk, which is huge considering lifetime death by cancer risk is 1/5) and have a daily fasting window of 13+ h (eg. Shown to reduce reoccurrence of breast cancer). I focused on cancer here, because intuitively it seems like a good marker for DNA maintenance.
Anyway, I think this is where some lifestyle fads can become interesting. Sure, there are definitely some aspects to aging that are unaffected by this, but I think better chances of reaching current max human age are in our hands somewhat. Balancing IGF1 and frequently giving the body a break to repair, kill, and remove trash, are sound targets IMHO. So for me that is: restriction of certein makros, in particular animal proteins and refined carbs, early and midlife to lower IGF1 (raising it seems beneficial in old people); short term fasting every now and then. Both have shown to increase apoptosis and repair. It's not even hard to do, if you stick to a blue zone typical diet (plantbased diets are associated with double digit reduction in overall cancer risk, which is huge considering lifetime death by cancer risk is 1/5) and have a daily fasting window of 13+ h (eg. Shown to reduce reoccurrence of breast cancer). I focused on cancer here, because intuitively it seems like a good marker for DNA maintenance.