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by restuijs
2908 days ago
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1. The polygenic effect is very small, r of .12 or .15 in the most stringent analyses. 2. The figures are pretty, but consider the restricted SES ranges, and the dominance of origin SES. Someone in a low SES origin group with high polygenic score was only reaching the lower middle class range in some cohorts. In ADDhealth, which in many ways is the most representative modern US cohort, there was very little effect of the polygenic score. Basically, origin SES has a huge impact, beyond the polygenic score, especially in certain cohorts. And this is within the restricted ranges of the figures. 3. European ancestry participants only. Pretty obvious why this is a problem. 4. There's some funny business with ages of parents relative to ages of participants when assessed. E.g. in some cohorts participants are being compared to the SES of their parents in young-mid adulthood, when they're in mid or late adulthood. |
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