There's really a night and day difference between CookieSafe style cookie management and what Chrome offers in terms of usability. CookieSafe is much nicer and no Chrome extensions seem to offer anything similar.
I haven't used CookieSafe but I have no doubt that its functionality is more advanced than Chrome's built-in options. Chrome doesn't expose the internal APIs required to control Cookie functionality to the extension system. So we're "stuck" with that Chrome gives us, which is more than good enough for my needs.