[jjw1414]

As a molecular biologist whose been in the field for nearly a quarter of a century (ouch, I'm old), I can't tell you how important your comment is. Too many times I've been to conferences where a small group of researchers is informally discussing a common roadblock in a procedure or technique and one in the group says, "We found out months ago that you can't use compound Y because it inhibits X downstream". For the love of all that is good, why didn't you publish that?! You could have saved countless combined hours and materials for other labs and increased the rate of progress. We all know the answer: Reviewers and editors want to publish flashy new discoveries, not fizzled experiments. Online discussions and open access has helped the issue, but the underlying pressure on scientists to publish only positive findings and leave out the critical trial-and-error data must end as it is is essentially fudging research and does a disservice to other researchers and science as a whole, intended or not. Whew, that was cathartic. I'll fade back into the shadows now.

[fallous]

I'd like to take the effort to thank you for staying true to the pursuit of real science and trying to demand that others meet the standards. A well-tested negative result is not a failed experiment, it is one less option to pursue.

As I've been known to tell junior engineers that ask how to become expert in some field, "the easiest way is to fail in every possible way without repeating yourself. Whatever is left is correct. Note that I didn't say that's the fastest way." Gaining new knowledge is always a combination of discovering both dead ends and possible successful paths.