[himom]

No, read the source article.

The validation data are taken at baseline from three previously published studies investigating pharmaceutical interventions to normalize metabolic abnormalities of children with ASD31: (1) a combination of methylcobalamin and low dose folinic acid32, 33 (2) high dose folinic acid,34 and (3) sapropternin.35 Given that these studies all focused on evaluating treatment strategies for ASD, all participants had a confirmed diagnosis of ASD. FOCM/TS metabolites were available for 154 (76% male) participants with ASD with a mean age of 8.8 years (range 2–17 years). These ages are different than reported by Delhey et al.34 because this study only required that measurements be available at baseline, rather than both at baseline as well as the conclusion of the treatment phase. Furthermore, stratifying patients by age or gender did not reveal any differences in the univariate metabolite distributions. The first two studies were approved by the IRB at the University of Arkansas for Medical Sciences and the third study was approved by the IRB at the University of Texas Health Science Center at Houston. All parents gave written, signed consent and patients provided assent when appropriate.

2.3 Metabolites

The metabolites under investigation are presented in Table 1 and additional details of these measurements and derivations are presented in Melnyk, et al.30 This is only a subset of the measurements investigated previously29 because “% DNA methylation” and “8‐OHG” were absent from the validation data set and were therefore removed from this study to ensure that a consistent set of metabolites are used for training and testing.

(Table 1 - 22 metabolic variables considered)

https://onlinelibrary.wiley.com/doi/full/10.1002/btm2.10095

I’m curious if these metabolic abnormalities apply to adults as well. I had an ADOS at the UCD MIND Institute come back with a 7 (1-14 scale IIRC) about 10 years ago.

PS: PKU treatment sapropterin (Kuvan) costs $100k USD/yr