[zaarn]

For Screen Readers I've found it helpful to use elinks or lynx to develop the initial HTML.

If your application remains readable and functional on a terminal output, chances are high a screen reader can handle it (since I can't afford any of the screen readers people seem to use, that's what I'm stuck with, aside from following general guidelines on this)

Progressive enhancing, the process of having a working HTML page, enhance with CSS/Images and then enhance with JS, is sadly a rather lost art in modern webdevs.