[rmgraham]

I've been full-time remote for just shy of 5 years and timezones is definitely an issue. Up to 4 hour difference is sustainable indefinitely, 8 hours can be with the right people (doing split days is great for this), but beyond 8 hours and the amount of effort required for synchronous communication (video calls) causes it to not happen and the team loses cohesion.

You need the synchronous communication to have non-work conversations, and you need those non-work conversations to develop and maintain the relationships required (trust, rapport, etc.) for remote work.

> if your organization ever becomes big enough to warrant a physical office

...then you probably don't have enough buy-in to be a fully remote company and that is far harder to work around than timezones.