[jlc]

PEP 8 is great, but (unless I've forgotten . . .) it doesn't really help w/ directory structure and so on.

I'd say take a look at some of the code in the standard library and in some other packages you've used before, then read this:

http://jcalderone.livejournal.com/39794.html

Then just go for it.

[eru]

And keep refactoring, when you get into a mess.