It depends. I generally use sbcl, unless I'm trying to do something with Cocoa, in which case I use either ccl or Lispworks CAPI. All my projects are open-source (MIT) and some of them are on quicklisp. I actually deploy applications by dumping an image and copying it to the right place.
I use emacs-with-evil mode + SLIME for developing applications... as I say, "the best implementation of vim is written in Emacs Lisp" or "evil-mode is the text editor for the Emacs operating system".