Audio Worklet https://developers.google.com/web/updates/2017/12/audio-work... is way, way cooler than these demos imply, as it actually gives you a high-priority digital signal processing thread separate from the UI thread. And because it can benefit from WebAssembly, it's only a matter of time before the power of native audio applications is ported to the browser.
Other comments have mentioned that this is coming to Firefox as well; core contributors on the media team have been discussing how it's a priority as recently as two days ago: https://bugzilla.mozilla.org/show_bug.cgi?id=1062849