[garrettdc]

I've seen some studies on this, but I (personally) haven't run across many that show a significant difference in isocaloric diets where carbohydrates are replaced calorie for calorie with fats.

If it is swapped with a mix of protein and carbs, then you have some confounding variables of the thermic effect of the protein to account for.

From what I have seen, keto diets work due to two things: 1) Reduced caloric intake due to chopping out carbs - a major swath of foods 2) Increased adherence due to stabilizing blood sugar levels and thereby increasing satiety (the whole "stay full longer" thing)

If you have other studies that have been shown significant in an isocaloric state, I'd love to see them. I just haven't run across any that have shown good control around these areas. I personally like keto (and bacon) so I'm always looking for another excuse to do it, but I don't think that there is a ton of evidence for it doing any hormonal magic in healthy populations at the moment.