[husainalshehhi]

If nihilism is true, then it follows that our lives are very little to no significance. And if that's the case, then we should do what pleases us rather what is right, since we have one life to live.

In any case, I think Alvin Plantinga has something good to say about science and religion in his book: science, religion, and naturalism, where the conflict really lies.

[uoaei]

The point of nihilism is that there is no "should." There are no logical conclusions from nihilism except all of them. If you feel a connection to fellow sentient beings, act in accordance with that. If you see them as your tools, then act so.

This frees up your moralistic framework to be solely realized by your own ethics. It takes some time to clarify and arrive at them, sure, but it necessitates an active engagement with the world and your influences upon it.

Or not. You could just use it as an excuse to live in hedonism or to off yourself. But that choice is entirely yours and you take ownership of it whether you want to or not.