[deegles]

Does anyone know where to get it in bulk form? The commercial stuff I've seen seems way overpriced.

Also, I'm happy for the disclosure but be wary of potential bias...

> The study was partially funded by grants from the National Institutes of Health and the American Federation for Aging Research. ChromaDex, the maker of NIAGEN provided supplements and some financial support.

[reasonattlm]

There are any number of suppliers other than the sole sanctioned one. Search Alibaba. Assume you will pay a fraction of what you'd pay the sanctioned suppliers, but you will also have to run a sample via a LC-MS analysis to see that you are in fact getting what you think you are getting. This is all pretty easy to arrange, and works for just about any well known compound, peptide, etc.

If you are willing to do that, one would hope that you are also willing to (a) actually assess the results with the more robust quantified self metrics, rather than just hoping and feeling, as so many people do, and (b) take full responsibility for any harms or legal issues you cause yourself in the course of experimenting, as so few people do.

The detailed guides section here contains a couple of posts that walk through this process for a couple of other items, but the same general outline applies in exactly the same way:

https://www.fightaging.org/self-experimentation/

[vondur]

I don't think the average person has access to a Mass Spec or Liquid Chromatography equipment.

[reasonattlm]

https://www.scienceexchange.com

$100-150 to run a sample through LC-MS via any one of dozens of small laboratory groups. Most are willing to explain things to a newcomer who is working his or her way through learning the ropes.

[refurb]

As a former chemist, I'd want to run a few more tests than just LC-MS. Like heavy metal levels and residual solvent levels.

Plenty of impurities don't show up in LC-MS.

[TheSpiceIsLife]

I'm often either:

a) surprised that processes that seemed futuristic or industrial are available to the average person at a reasonable price

or

b) surprised that others are surprised

I operate a 4kW laser cutter set up to cut metal. Once new customers realise how much product the machine can put out in an hour they understand that it isn't an expensive service, and that it is in fact almost always cheaper to have an item laser cut rather than do it themselves using any of the tools they have in their workshop.

[GordonS]

Anyone here know if anything like this is a available in the UK?

[adrr]

You can't get in bulk. Chromadex stopped all licensing of its patent so you can only buy it from them at $40/m. Chromadex is exploring FDA approval for certain medical conditions so it will be interesting to see if they keep it on the retail market or it becomes prescription only.

[e9]

Just use high quality niacin/nicotinic acid/vitamin-b3. "niacin supplementation increases cellular nicotinamide adenine dinucleotide (NAD+) levels"

reference: https://examine.com/supplements/vitamin-b3/

[truculation]

Yes and be prepared for that 'niacin flush' if you take a 500mg capsule the first time. Phew. I had to lie down for half an hour.

https://niacinreviews.com/niacin-max-flush/

[VoiceOfWisdom]

Beware the niacin flush. Once I took 500mg, after having already been accustomed to the flush. It hit hard that day though. 15 minutes after taking the pill, while driving, my vision started to narrow and go black. It felt like being chocked out. I was rapidly losing consciousness, but was able to safely pull over to the side of the road. Before completely passing out I was able to vomit up what was left of the pill. I was able to return home, and sleep for the rest of the day. This was with a single 500mg pill, after already being used to the flush.

[mistermann]

FWIW, and not sure if this only helps the itching part of the side effect....

https://www.leaf.tv/articles/how-to-relieve-an-itch-from-nia...

Drink plenty of water. According to Dr. William Davis, a cardiologist from Wisconsin, ingest 2 8-oz. glasses of water immediately after the itching sensation begins. According to Dr. Davis, this quick task relieves the flush and itching symptoms in more than 90 percent of instances.

Take a 325mg table of uncoated aspirin; according to Dr. Davis, this can also alleviate the itching and burning.

[eljimmy]

I had no idea about this before taking it. I popped some before going to the store. Thought I was about to crap myself then started getting super itchy. Had to rush home and by then my entire body was lobster red lol

Definitely want to use the non flushing version.

[JohnJamesRambo]

Are you sure you get a similar effect? A quick search suggests niacin behaves quite differently.

https://www.quora.com/What-is-the-difference-between-nicotin...

"Among "salvageable precursors" (i.e., Na, Nam, NR), a lot of focus is on NR these days because apparently it activates the "anti-aging" sirtuin genes at high concentrations too compared to Na and Nam which only activate those "longevity" genes only at small concentrations and deactivate them at higher concentrations."

https://www.ncbi.nlm.nih.gov/pubmed/18429699

"Because current data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis"

[amelius]

I've been taking Niagen for a couple of months, and I can say that for me it feels much better than niacin or niacinamide. I don't know why (perhaps I have some niacin metabolism problem, or the niacin interferes with some other impaired process such as the methylation cycle).

Also there seems to be some synergy between Niagen and resveratrol and pterostilbene that I can clearly notice. Foods that work well with Niagen are raisin(-bread) and olive oil. Of course, ymmv.

[e9]

That's interesting. Glad that you are experimenting! Everyone is so different that experimenting is the only way to find out what works and what doesn't for anyone :). Just curious, what other supplements did you find working out for you?

[amelius]

When a doctor's visit leads to a dead end, then yes, I believe experimenting is probably the only option left.

I've taken a lot of supplements in the past, but at some point I found out that stomach acid and digestion were the problem.

[Zigurd]

I have read pieces on NR that claim NR is better at "activating" sirtuin production compared with niacin. Is this a load of baloney? Or is NR really different in its effect?

[p0wn]

As far as I know it's fairly hard to synthesize, and isn't produced in large quantities yet.

[delbel]

Smoking cigarettes would do it. Nicotine + Oxygen right? Who knew the movie Sleeper had it right, keto diet and tabacco. https://www.youtube.com/watch?v=D2fYguIX17Q

[klipt]

Smoking certainly reduces your chance of dying of old age. Mostly by increasing your chance of dying of lung cancer.

[jackhack]

Perhaps an argument for "vaping," then? (Nicotine without the smoke and tar and other nasty compounds in tobacco.)

I never thought I would say that.

[dogma1138]

Thorne has a fairly cheap one but I’m not sure how much more effective any of those are than high dose B3.