USAF wargames discovered against F22s the most effective strategy to use would be tanker denial. Tho' with 4th generation fighters you would still need to outnumber them 6:1 (!)
The astronomer Freeman Dyson was part of the operational analysis team in WWII that worked out it made most sense to only search for and attack refuelling and resupply U-Boats (milkcows)
The Vulcan flight gear famously included hiking boots so the crews could walk to Turkey after completing their mission