Hacker News new | ask | show | jobs
by FlyingSideKick 3005 days ago
I’ve been considering taking these supplements but I’m concerned about increased risk of cancer. Have there been updates on this since the publication of this study? https://siteman.wustl.edu/pathway-linked-slower-aging-also-f...
1 comments

Just skimmed the article, and it seems to me that they are more looking into this to find a treatment for brain cancer than making a direct causality from the supplement itself. Basically when someone does have brain cancer, they could limit NAMPT to help in treatment. That's how I read it at least, maybe I'm misinterpreting. There is these quote:

“We didn’t directly demonstrate that taking NAD+ precursors makes tumors grow faster, but one implication of our work is that if you want to take anti-aging NAD+ precursors, you might want to keep in mind that we don’t yet understand all the risks.”

"Furthermore, the scientists found that glioblastoma cells responded to radiation therapy – a standard therapy used to treat the disease in people – by increasing expression of NAD+ pathway genes, and that inhibiting NAMPT before dosing the cells with radiation made them easier to kill."