[andrewaylett]

I've used Dvorak as my primary layout for ~12 years now, and I'm just as capable at typing on QWERTY. Colleagues object if I set servers and test machines to a different keyboard layout.

The biggest struggle is words beginning "am" or "ma", the two keys which are in the same location on both layouts.

If you can learn to cope with changing between a Mac and non-Mac then you can learn to cope with changing keyboard layouts.

I'd recommend using only one layout when learning though: I switched solely to Dvorak when I was learning, then learned to use both side-by-side afterwards.