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by epmaybe 3031 days ago
Here is the actual paper, with abstract: https://www.nature.com/articles/nbt.4071

Major things that are interesting just from the abstract: 1) their targeting dna aptamer binds to nucleolin (how this isn't binding to the nucleolin in normal cells is beyond my knowledge, but my guess is that the protein is expressed somewhere other than the nucleolus of the tumor cell). 2) Doesn't seem to affect mice without tumors, so a good thing?

1 comments

Thanks! I figured it must have been that tumors express nucleolin on the surface rather than normally inside of the nucleolus.