[Florin_Andrei]

The plasticity of the brain is tremendous. I would not be surprised if it turns out that long-term meditation and other techniques not only reverse damage from depression completely, but eventually leave their own signature changes (which are beneficial) on the brain's structure.

[conjectures]

Oh they do leave a trace. Plenty of neuroimaging papers I've not read are on long term meditators. There's a good Sam Harris ep. on this topic.

https://samharris.org/podcasts/111-science-meditation/