Hacker News new | ask | show | jobs
by IntronExon 3032 days ago
The cells lining the entire upper GI are exposed to digestive enzymes, and are perforce replaced rapidly and constantly. Until bicarbonate rich bile is added to the mixture in the duodenum, those enzymes (and acids) eat your own cells too. Chemotherapy plays havoc with your GI tract because it selectively kills cells which rapidly divide.

As for histamines, mast cells are designed to respond to them and rupture as part of your inflammatory cycle. They release more cytokines, recruiting neutrophils and in general telling your immune system to attack.

1 comments

Histatins, not histamines.
Oops, thanks for the correction!