[m00g00]

Note that this is already kinda the case for fretless instruments, such as the violin. What you are suggesting to be done by a computer would be done by the player themselves. Obviously deciding exactly what tuning of each note to land on for any part of a song relies on musical intuition which computers are notoriously bad at. But when decided to be appropriate, on the violin perfect 5ths and 4th intervals would be actually (to the limits of the players ability and ear) perfect ratios. The major 3rd itself, which is decidedly enharmonic in equal temperament would sound cleaner and less "beaty".

I've always thought Bach would love the keyboard tools we have today. Simply the ability to switch tunings on the fly, rather than stopping to laboriously change gears on your harpsi/clavichord. I imagine the ability to switch to whatever temperament/tuning you want at the press of a button would have masterfully been taken advantage of by him (to say nothing of arbitrary sound/timbre for each voice/key-range etc. I think he would have loved Switched-On Bach).