[dr_coffee]

I work on protein structure, albeit not from a computational standpoint, and it struck me as odd that none of the work from the Baker group (Univ Washington) e.g. Rosetta (https://www.rosettacommons.org/) was mentioned. Rosetta can be used to predict tertiary structure from amino acid sequence. Does anyone familiar with the field know how the methods used by software like ROSETTA differ from those presented in this paper?

[superfx]

Hi! I’m the author of the paper. Not sure why you say Rosetta isn’t mentioned? It’s extensively referenced throughout the paper, discussed in the discussion section, and is one of the top 5 CASP servers compared to in the results section.

Also as for how it’s different from what’s described in the paper, that’s the topic of the introduction of the paper. Rosetta uses both fragment assembly and co-evolution methods.

[dr_coffee]

Oops I seemed to have skimmed it a bit too quickly. Thank you for the kind reply.