[jdietrich]

Yes. "Recreational" users rarely suffer from ket bladder - it's people with serious addictions who are ending up in urology clinics. Users are reporting taking anything from 5 to 15 grams per day; even assuming that it's of very low purity, that's still orders of magnitude more than the doses being used to treat depression.

[atomical]

Ketamine is toxic to the bladder at any dose. I haven't found any long term research on this topic.