That's inbound traffic coming from the outside world. You need NAT because the load balancer only knows about nodes, not individual pods (perhaps you can pull it off with e.g. ELBv2, but definitely not with v1).
There's more iptables magic if you talk to a service's virtual cluster IP, because of the load balancing, but from pod to pod, which is what I thought you were referring to, NAT is usually not involved.
Are you referring to the service cluster IPs? Those are great for short lived or low volume connections. If you want to balance load over long lived connections or have high volume, you really want to know the addresses of all your backends, whether that's done in your code or in a sidecar like Istio's.
There's more iptables magic if you talk to a service's virtual cluster IP, because of the load balancing, but from pod to pod, which is what I thought you were referring to, NAT is usually not involved.