[microtonal]

As always, it depends on your threat assessment and what is practically possible. For the vast majority of users, using a password manager browser extension [1] is a large improvement over password re-use over dozens of sites. Most folks will also not want to put in the effort to use an out-of-band password manager.

(Not directed at you personally, but I often hear such comments from people who are then perfectly fine to use a password manager in X11, where in a the default configuration every application can read your keystrokes, screen grabs, clipboard, etc.)

[1] Preferably one that communicates with an out-of-process password manager over an authenticated channel like 1Password.