[ataylor32]

One scenario I can think of is a non-IE user telling an IE user to go to a particular website and click the button that's at the top of the right sidebar. For the IE user, it might be a stacked layout where the sidebar actually appears under the main content. I would call this a nuisance more so than a major issue, but nevertheless it is something to consider.

[_betty_]

you'd have the same issue between a desktop and mobile user. i don't see it as an issue at all.

[ataylor32]

I think the average computer user knows that websites often look different on computers vs. phones, so they might be confused when a website looks different than normal on a computer. Like I said, I would only call this a nuisance. Certainly not a big deal.