[nextos]

I'm not a big fan of Fortran for my particular domain, which includes lots of strings (biological sequences). Here Fortran is not as quick. See for example the k-nucleotide benchmark:

https://benchmarksgame.alioth.debian.org/u64q/performance.ph...

[pjmlp]

I worked with a customer that was using .NET for DNA sequencing.

Not sure what tricks they pulled off regarding unsafe code and parallelism, but it was fully done in C#.