| A note about one of the comments there related to Aspirin, namely, this one: https://news.ycombinator.com/item?id=16102328 There's an alternative solution for the stomach lining issue: https://en.wikipedia.org/wiki/Carbasalate_calcium Which reminds me, this testicle study seems to fail to distinguish Dex(tro)ibuprofen from Levoibuprofen. That seems rather disappointing, as we've known about the difference between the two for quite a while. This continued ignorance of medical science when it comes to (stereo)isomers never ceases to amaze me. I mean... You'd think they'd have learned their lessons by now. (Then again, we also still fail to employ multi-compartment models of pharmacology in the vast majority of studies. And... ugh. I'll avoid ranting on how shitty medical science seems to me and just leave it at this.) [btw., if you wonder why you can't get your hands on Dexibuprofen in the US: "Open committee discussion. The committees will discuss new drug application (NDA) 20–373, S+ Ibuprofen (dexibuprofen, Sterling Winthrop/ Bayer) 200-milligram caplet, indicated for the temporary relief of minor aches and pains associated with the common cold, headache, toothache, muscular aches, back ache, menstrual cramps, minor pain of arthritis, and for the temporary reduction of fever for OTC status." From the Federal Register, from 1996. It never got approved, and one can't even find the application on the FDA page, thus one can't find out more about why it never made it to market!] |