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by raverbashing 3070 days ago
While the results do matter, this is probably being blown out of proportion

> One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk

Yeah, that's a lot of Ibuprofen for a long time

5 comments

Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.
I'm not saying it's an overdose (and their tests of renal and hepatic function corroborate that)

But it's not a dose people will commonly take in their "day to day" activities and ideally not something that is done without medical supervision

It's one of the features of Ibuprofen that you can take it at those levels without killing yourself. Most people don't, but some people do - sometimes because doctors tell them to.

This makes it different to Paracetamol, where you only have to double or triple the standard dose to cause temporary liver damage, and increasing it only slightly further puts you in danger of death.

> it's not a dose people will commonly take in their "day to day" activities

A lot of people who exercise multiple times a week take "Vitamin I" every day. So do people who have frequent headaches, back or joint pain, etc. I probably came close to these levels during a bout of plantar fasciitis, though I've since switched to naproxen in such cases. It might not be common in your immediate circle, but in the broader world it's not rare enough to raise any eyebrows.

I went through a period of heavy physical activity without good equipment, which caused quite bad shin splints. My doctor prescribed precisely this dose, along with some physiotherapy. I think it's quite common for inflammatory problems like that.
I disagree. People regularily take 800mg of ibuprophen for regular/tension/miagrane headaches. These can be quite regular and chronic occurances.
When I would visit military doctors, they would prescribe 1g pills like they were a panacea.
Wow, all the ones I have (and I don't remember seeing any different in Australia) all say do not take for more than three days at a time (except with a doctor's advice).

6 weeks is a long time to be popping 1200mg/d!

Are you sure it didn't have codine in it? In the UK, the only (AFAIK) non-prescription medication with that sort of warning is anything containing codine.
I'm in Australia and looking at a box of plain Ibuprofen. It also recommends limiting to a few days at a time unless told otherwise by a doctor.
And I believe the max dose is even higher - 3200mg per day (800mg 4 times per day).
Correct. Adults can take up to 800mg q6hrs and I routinely prescribe that dosing after ankle sprains, etc for a few days. 6 wks duration would be way out of my comfort zone.
I don't have the PDR handy but I thought it was 2400 mg/day-- 800mg * 3. (It's based on kg/body weight IIRC, but that was the indicated quantity.)
I don't have the PDR handy but I thought it was 2400 mg/day-- 800mg * 3. It's based on kg/body weight IIRC, but that was the indicated qu amount
Yep. a good friend is a doctor who does triage in an ER (amongst other things) - he said 'We start at 1500mg doses'.
I've been prescribed that sort of dosage to deal with inflammatory issues. From limited personal experience, larger does are not about pain relief, but bringing inflammation (eg bursitis) under control.
I've been through similar doses as well, though for muscular strain I was given something stronger (not opioids though)
Have you seen how some people gobble this stuff?

I've felt compelled to say to more than one person: probably shouldn't take that much ...

Sometimes pain management is a balancing act between dangerous side effects and misery that makes it hard to want to keep living. Chronic pain isn't really something a third party can make decisions about; it may be that ibuprofen isn't the right choice, but lots of other choices (opiates, for instance) may have even more negative effects (like addiction and risk of deadly overdose).

Of course, there are folks who take over-the-counter meds as though it is safe at any dose and frequency. That might warrant a nudge toward reading the label about safe dosage, or a mention of a recent study on the subject.

Exactly this. I have a chronic wrist injury from a previous job. Physiotherapy hasn't really helped, and the only thing that does help when I have a bad day is naproxen (another NSAID in the same class as ibuprofen). I feel guilty taking it in the dose I do (1000mg/day) but it's the only thing that makes life bearable and makes me functional.
I've known plenty of people who do 400mg 2-3x/day for weeks/months.
Military?
Collegiate and professional athletes easily would do this. (I've personally done it, hell.)

Construction workers, manual laborers, etc.

True.

A lot of people I know that powerlift do 4 x 800mg for 5 days or so. I think the thinking is to give the injury a "blast" of ibuprofen to bring the swelling down fast, rather than a lower dose for a longer period.

Yes (and contractors, etc.)
I remember reading in a Tom Clancy book once that it's called "Light Fighter Candy".
Six weeks isn't a long time if you've got a herniated disc.
Correct, hence if you need pain control for longer than 6w there might be other options
I know that certain herbal cookies work vastly better than ibuprofen, even a day after intake, but they're not prescribed very liberally around here.