[toomanybeersies]

I don't know if the human brain could handle that. If you have too many fun nights out, they start to wear. If you take too many drugs, they start to lose the magic, they just become normal.

You need the highs with the lows.

[spondyl]

I suppose if we got to that point, you could replace that portion of the brain with cybernetics, save the state before having taken any drugs then every so often, flash it back to the beginning?

[Godel_unicode]

If you haven't read Peter F Hamilton's Commonwealth saga, you might appreciate it. Memory editing plus effective immortality is an interesting concept.

[djsumdog]

Best expressed by the philosophy of Butters:

https://vignette.wikia.nocookie.net/southpark/images/b/b3/A_...